INTRANASAL DELIVERY OF A CHIMPANZEE ADENOVIRUS VECTOR EXPRESSING A PRE-FUSION SPIKE (BV-ADCOV-1) PROTECTS GOLDEN SYRIAN HAMSTERS AGAINST SARS-COV-2 INFECTION

We evaluated the Diffuser immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.Intranasal administration of BV-AdCoV-1 elicited strong humoral and cellular immunity in the animals.Furthe

Distribution network security situation awareness refers to the process of perception, understanding, and state projection of systems, elements, and environmental factors within a certain space-time volume.Security situation awareness is an important part of the security assessment of the distribution network.In response to the rapid and accurate d

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a pandemic by the WHO in March 2020.As Hangover Formulas of August 2021, more than 220 countries have been affected, accounting for 211,844,613 confirmed cases and 4,432,802 deaths worldwide.A new delta variant wave is sweeping through the globe.While previous repor

Colon cancer has a high rate of recurrence even with good response to modern therapies.Novel curative adjuncts are needed.Oncolytic viral therapy has shown preclinical promise against colon cancer but lacks robust DC Output efficacy in clinical trials and raises regulatory concerns without real-time tracking of viral replication.Novel potent vector